Marble Burying Test Anxiety

It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19.

Marble burying test anxiety.

The marble burying test is used to record the number of marbles buried by mice placed in a novel environment. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. The elevated plus maze epm test is used to evaluate the relative anxiety status of mice or rats.

We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits. It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior.

When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in novel contexts potentially as a means to attempt. Marble burying as an anxiety model in conclusion although marble burying was reduced by doses of diazepam and zimeldine which did not affect activity in a locomotor test we have not been able to find other evidence that marble burying models anxiety either from its behavioral characteristics or from the actions of anxiogenic agents. From here it can walk down any of four runways. This test has some predictive value for anti depressant and or anxiolytic drugs.

The epm situation rests on the conflict between the innate tendencies of rodents to explore novel environments and avoid open and brightly lit areas. The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. The marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. In this unit behavioral tests are described that are relevant to the domains affected in asd.

Mice which are placed individually in a cage bury glass marbles that are present in the cage. For the repetitive domain the t maze spontaneous alternation test and marble burying test are described. In this task the animal is placed in the centre of the maze. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior.

Marbles are placed evenly onto the walls of an empty cage. Since findings reported in the literature indicate that marble burying behavior. The animal is then placed in the cage containing the marbles. The mouse is treated with the vehicle or compound 30 minutes before the test.